我知道很多癌症患者都有在吃巴西蘑菇

今天我找到一些資料

我覺得有必要提醒乳癌病患

資料附上請大家自己看吧

1. Agaricus blazei (class Basidiomycotina) aqueous extract enhances the expression of c-Jun protein in MCF7 cells.

名詞解釋

Agaricus blazei:巴西蘑菇

aqueous extract :水溶性萃取

c-Jun protein:jun基因製造的蛋白質(jun是一種原致癌基因)

MCF7 cells: 乳癌細胞的名字,實驗室裡做實驗用的

 

根據wiki的解釋 : Overexpression of c-jun in MCF-7 cells can result in overall increased aggressiveness(細節請自己點進去看)

 

2. Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricusblazei mycelia.

estrogenic: 具estrogen作用的

 

 

相反的資料

Novel medicinal mushroom blend suppresses growth and invasiveness of humanbreast cancer cells.

不過這是多種菇混合,不是只有巴西蘑菇

 

為了安全起見

還是建議乳癌病患要吃菇類可以多吃其他種菇

少吃巴西蘑菇比較好

不過這只是針對乳癌病患

其他病人沒關係

事實上

根據我找到的資料

巴西蘑菇對於很多癌症是有幫助的 : http://www.ncbi.nlm.nih.gov/pubmed/?term=Agaricus+blazei+%2C+cancer

 

註: 原致癌基因(Proto-oncogene): http://highscope.ch.ntu.edu.tw/wordpress/?p=42585

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以上原文寫於20151201

更新(20171127)

新找到的文章

Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

巴西蘑菇的確具有estrogen的作用,

但是直接把巴西蘑菇跟乳癌細胞MCF7一起培養

卻可以抑制MCF7

並且是成dose-dependant (劑量越大效果越強)

We first examined the effect of the A. blazei extract on cell growth using breast cancer MCF-7 cells and found that the extract inhibited cell growth in a dose-dependent manner, 50% at 4 μg/ml and 80% at 6 and 8 μg/ml (data not shown). This finding was not surprising because such inhibitory activity had been reported (Grube et al. 2001). We assumed that any potential estrogen-like activity would be masked by this growth-suppressive effect. We therefore examined whether the A. blazei extract shows activity similar to estrogen at the gene expression level using a customized DNA microarray containing a set of 150 estrogen-responsive genes (Fig. 1A). Similar expression profiles were obtained between cells treated with 10 nM E2 and those treated with 2 μg/ml of the A. blazei extract (correlation coefficient or R = 0.84), suggesting the presence of estrogen-like activity in the extract. The 150 genes were further categorized into six groups with specific functions (enzymes, signaling, proliferation, transcription, transport and others) and used for a correlation analysis (Fig. 1B). Significant correlations were observed between the A. blazei extract and E2 for the groups enzymes, signaling, transcription, transport and others, while a significant but less correlation was observed for the group proliferation (Fig. 1B).

 

 

想看其他關於臉部保養的文章,請點這裡

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